(credit a “micrograph”: modification of work by USDA ARS credit b “micrograph”: modification of work by U.S. These researchers hope one day to better understand the origin of viruses-a discovery that could lead to advances in the treatments for the ailments they produce.įigure 2: Viral capsids can be (a) helical, (b) polyhedral, or (c) have a complex shape. The emerging field called virus molecular systematics attempts to do just that through comparisons of sequenced genetic material. In all cases, viruses are probably continuing to evolve along with the cells on which they rely on as hosts.Īs technology advances, scientists may develop and refine additional hypotheses to explain the origins of viruses. A third hypothesis, the self-replicating hypothesis, suggests that viruses may have originated from self-replicating entities similar to transposons or other mobile genetic elements. A second hypothesis, the escapist or the progressive hypothesis, suggests that viruses originated from RNA and DNA molecules that escaped from a host cell. However, many components of how this process might have occurred remain a mystery. One such hypothesis, the “devolution” or the regressive hypothesis, suggests that viruses evolved from free-living cells, or from intracellular prokaryotic parasites. There are current evolutionary scenarios that may explain the origin of viruses. Most scholars agree that viruses don’t have a single common ancestor, nor is there a single reasonable hypothesis about virus origins. However, viruses do not fossilize, as far as we know, so researchers must extrapolate from investigations of how today’s viruses evolve and by using biochemical and genetic information to create speculative virus histories. When exploring the evolutionary history of most organisms, scientists can look at fossil records and similar historic evidence. The use of electron microscopy and other technologies has allowed for the discovery of many viruses of all types of living organisms.Īlthough biologists have a significant amount of knowledge about how present-day viruses mutate and adapt, much less is known about how viruses originated in the first place. The surface structure of virions can be observed by both scanning and transmission electron microscopy, whereas the internal structures of the virus can only be observed in images from a transmission electron microscope. It was not until the development of the electron microscope in the late 1930s that scientists got their first good view of the structure of the tobacco mosaic virus (TMV) ( Viruses: Introduction: Figure 1), discussed in the previous chapter, and other viruses (Figure 1, below). With the exception of large virions, like the poxvirus and other large DNA viruses, viruses cannot be seen with a light microscope. However, some recently discovered viruses from amoebae range up to 1000 nm in diameter. Most virions, or single virus particles, are very small, about 20 to 250 nanometers in diameter. Still, it was many years before it was proved that these “filterable” infectious agents were not simply very small bacteria but were a new type of very small, disease-causing particle. In 1892, Dmitri Ivanowski showed that this disease could be transmitted in this way even after the Chamberland-Pasteur filter had removed all viable bacteria from the extract. In 1886, Adolph Meyer demonstrated that a disease of tobacco plants- tobacco mosaic disease-could be transferred from a diseased plant to a healthy one via liquid plant extracts. Viruses were first discovered after the development of a porcelain filter-the Chamberland-Pasteur filter-that could remove all bacteria visible in the microscope from any liquid sample.
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